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Finally, the absence of gut microbiome and hepatic metabolism data limits mechanistic interpretation, particularly for diet-responsive metabolites such as coumarin

Tirzepatide is a dual GLP-1 and GIP receptor agonist, often described as a twincretin. It is a single synthetic peptide designed to activate two incretin receptors simultaneously rather than one

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J Transl Med (2020) 18:290

10.1111/j.1471-4159.1975.tb04369.x 303 JosefssonE.O'connellD.FosterT