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This benefit appeared independent of weight loss, suggesting direct cardiovascular protective effects from GLP-1 receptor activation

Total weight loss by week 12 typically ranges from 5% to 8% of starting body weight, depending on the medication and dose

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Conversely, mice defective for both the receptors for glucagon and GLP-1, or GLP-1 and GIP, show a highly plastic entero-pancreatic system that adapts and gives these animals no overt phenotype in terms of glucose homeostasis (105)

Surgery is usually reserved for patients who have very large goitres (enlarged thyroid glands) that cause compression symptoms such as difficulty breathing or swallowing, who have eye problems due to Graves disease (Graves ophthalmopathy), who have suspicious nodules or cancer in the thyroid gland, or who are not suitable for or refuse anti-thyroid drugs or radioactive iodine therapy