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Similarly, exercise elevates metabolism, causing an increase in the use of oxygen and eventually resulting in oxidative stress 16 , 17

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Further, we demonstrated morphine inhibits PVN Glu neuronal activity through the MOR, which in turn leads to suppression of its tonic NMDA receptor-mediated currents to DMV Ach neurons, and ultimately, the overall hypoactivity of this circuit mediates small intestinal dysfunction

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