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Protein bands were visualized using chemiluminescence (ECL, WBKLS0500, Millipore)

Reported weight loss at that approved tablet dose (about 11.1%) is essentially the same as the 11.2% seen with the trial capsule

The molecule that emerged from this foundational work carried a disabling flaw as a therapeutic scaffold: native GLP-1 is degraded almost immediately by the serine protease dipeptidyl peptidase-4 (DPP-4), which cleaves the peptide between residues 8 and 9 and confers a circulating half-life of under two minutes [4]

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