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Tirzepatide works to address the timing mismatch by: Slowing gastric emptying which delays how quickly glucose enters the bloodstream Supressing glucagon (a hormone that raises blood glucose) which will help reduce post-meal spikes Reducing appetite which lowers food intake and daily insulin requirements Together, these effects may reduce the mismatch between food absorption and insulin action, making it easier for an automated system to maintain stable glucose levels without manual intervention

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A dual-action GLP-1/GIP receptor agonist that has shown even greater weight loss results than semaglutide in head-to-head trials up to 22.5% body weight reduction

Cleveland Clinic Journal of Medicine, 92 (1), 3339