10 GLP-1s also reduce visceral fat, the metabolically active fat stored around internal organs that feeds this cycle in the first place
Liraglutide, a glucagon-like peptide-1 receptor agonist, ameliorates inflammation and apoptosis via inhibition of receptor for advanced glycation end products signaling in AGEs induced chondrocytes
Common nutrients of concern Vitamin D Important for bone, muscle and immune health Deficiency is common, especially in people with obesity Calcium Essential for bone strength Blood levels may appear normal even when intake is low Vitamin B12 Supports nerve function and energy metabolism Low levels may cause fatigue, numbness or cognitive changes Magnesium Involved in muscle function and energy production Often under-consumed in general diets Iron Important for oxygen transport in the blood Risk may be higher in menstruating women Signs of possible deficiency Fatigue Muscle weakness Hair loss Slow wound healing Unusual bruising Should you take a multivitamin
Timing the GLP-1 injection appropriately relative to oral medications is a practical consideration
What support is available for our family
Upcoming CVD outcome trials, such as the EXSCEL study of exenatide weekly, the LEADER study of liraglutide and the REWIND study of dulaglutide might provide further insight in this matter (Table 1)