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This group of cells is often implicated in inflammatory and degenerative disorders of the brain ( Classically the study of demyelination in disease has focused on oligodendrocytes, as those cells are primarily affected, but recent literature has shown an emerging role of other glial cells, particularly astrocytes and microglia, in regulating not only myelination but also neuroinflammation and neuroplasticity in the course of the disease ( As different mechanisms at a cellular level may be the cornerstone of developing more accurate biomarkers and effective DMTs, it is imperative to study the different influences which glial cells may exert in primary demyelinating phenotypes

So that's how doctors have been making those diagnoses and how they've been using those definitions

After twenty-eight days of treatment, there was no difference in DNA synthesis in C3H and B6C3F1 mice and reduced DNA synthesis in C57BL and C3B6F1 mice

-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasing acute-phase insulin secretion

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-tocopherol is the principal member of vitamin E with antioxidant property