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A few commenters noted that dual-eligible proportion is a useful proxy for socioeconomic risk but does not differentiate between patients with complex pain syndromes and those with other chronic conditions

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In selecting a third agent added to metformin and DPP4 inhibitor, the ADA/EASD guidelines recommend selecting one of the agents among sulfonylurea, thiazolidinedione, SGLT-2 inhibitor or insulin, whereas other agents, including -glucosidase inhibitor, are generally not favored because of their modest efficacy and frequency of administration [2]