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Because these medications target distinct biological systems, concurrent use does not create direct pharmacological conflict at the receptor level

The 'LR3' designation refers to a 13-amino-acid N-terminal extension and a glutamic acid substitution at position 3, which together reduce binding affinity for IGF-binding proteins (IGFBPs) by approximately 100-fold

Statistical analysis All statistical analyses were done using the SPSS software (version 23

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