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Although animal models offer preliminary insights, they do not always replicate human metabolic processes, potentially leading to different bioavailability and efficacy in humans

26,382,383 Intravenous injection of LDHA/B inhibitor NCI-006 inhibits LDH activity and its growth in pancreatic cancer mouse models, so as oral administration of LDHA inhibitor GNE-140

If additional glycemic control is needed, the dose can be further increased to 1 mg and 2 mg once weekly

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