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We found that the amount of AngIV in mouse tissue increased after the administration of Dihexa compared to that in the WT group

The guanine and deoxyguanosine oxidation products 8-oxoG and its nucleotide 8-oxo-2-deoxyguanosine (8-oxodG) are ROS-mediated DNA lesions considered the most significant biomarkers for oxidative DNA damage (40)

Moreover, monocytes exposed to BDG for 4 hours have a different transcriptomic program compared to resting monocytes and monocytes exposed to BDG for 1 hour and 24 hours (PC2)

Simultaneously, it is clear that there are significant differences in clinical evidence, efficacy, safety, target population, and cost in these studies