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The intracellular glutamate concentration is nearly 10-fold higher than the Km value, but intracellular cysteine concentrations approximate the apparent Km value [10] , indicating that cysteine may be a limiting substrate for GCL

Lewis, W

IJMS 21 , 6412 (2020)

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During each of the Phase II interventions, participants only consumed provided, standardized meals with limited L-carnitine, choline, and ellagitannins ( 200 mg/day for choline and L-carnitine), based on United States Department of Agriculture FoodData Central and published literature ( To validate the 48-h run-in diet, a coefficient of variation (CV) in baseline plasma TMAO was calculated across three fasting measurements (Phase I baseline, Phase II intervention 1 baseline, and Phase II intervention 2 baseline)

Based on this information, for most patients, a tesofensine dose of 0.5 mg or lower appears to be the most suitable option