Participants were randomly assigned to receive once daily orforglipron (12, 24, 36, or 45 mg) or placebo for 36 weeks as an adjunct to lifestyle intervention that included education regarding healthy eating and exercise provided by trial personnel
Sugar-free options designed for diabetics are often better tolerated
Patients should be aware that long-term use can be cost-prohibitive
Altogether, these findings suggest that intrauterine stressors elicit sexually dimorphic adaptations in glucocorticoid sensitivity in key tissues such as the placenta, with female neonates showing upregulation of highly sensitive GR isoforms, potentially leading to increased sensitivity to glucocorticoid-mediated growth inhibition
Currently, there is no official link established between Mounjaro (tirzepatide) and restless legs syndrome in the approved prescribing information or clinical trial data
Fang B, Liu F, Yu X, Luo J, Zhang X, Zhang T, Zhang J, Yang Y, Li X