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Neuronal activation mapping using cFos immunostaining in the area postrema (AP), nucleus tractus solitarius (NTS), and lateral parabrachial nucleus (LPBN) provided mechanistic insight

It was found through preliminary research that treatment with AOD9604 over the course of 14 days in obese mice led to decreased body weight and body fat and was shown to increase the activity of the beta(3)-adrenergic receptors in the fat cells to the same level as those in lean mice

Semaglutide 2.4 mg (Wegovy) produces approximately 15-17% weight loss in similar trials

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