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Ansorena E, Garca-Trevijano ER, Martnez-Chantar ML, Huang ZZ, Chen L, Mato JM, Iraburu M, Lu SC, Avila MA (2002) S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells

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Explanation: Skin tone is primarily determined by genetics, and there is no natural or permanent way to drastically alter it

And so I think that's another mechanism

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