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Once absorbed into the bloodstream and taken up by the cells, this exogenous glutathione immediately goes to work neutralizing the rampant reactive oxygen species (ROS) that are damaging the mitochondria

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We found that expression of GPX4 was reduced after Cys 2 starvation and erastin treatment, further proving that ferroptosis is a primary mechanism of GSH depletion-induced cell death in RPE (Fig

Mitochondrial metabolite transport

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