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The extracted supernatant was used for analysis by UPLC

However, the rapid GSSG accumulation reported for such conditions is only transient as GSSG is efficiently exported from cultured murine astrocytes via Mrp1 (Figure 2) (Arend et al

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A recent study also demonstrated mislocalization of APE1 from the nucleus to the cytoplasm as a possible trigger of oxidative DNA damage in spinal motor neurons expressing mutant SOD1 G93A , despite upregulation of multiple DNA repair enzymes, suggesting that restricted localization of APE1 could inhibit redox homeostasis (Li J