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It would be the first GLP-1based obesity therapy requiring only monthly injections

Abstract Obesity is a powerful driver in the development and progression of osteoarthritis (OA), contributing to increased mechanical load and metabolic stress, making it a valuable target for treatment

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[PMC5256913] Mitochondrial Health : By reducing oxidative stress in mitochondria, ergothioneine supports energy production and reduces the risk of mitochondrial dysfunction, which is linked to various age-related diseases

Retatrutide is not yet FDA-approved for obesity treatment as of October 2025

[ii] Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K