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The GIP receptor activation appears to reduce nausea compared to pure GLP-1 agonists, which is why retatrutide shows a 28% nausea rate versus 44% for semaglutide despite being more potent

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Wilsons is an autosomal recessive disease with an estimated incidence of 1:30,000 live births internationally.2 The most common presentation is in the second decade of life with hepatic or hematologic symptoms (4060%)