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A significant increase in serum lipoprotein lipase (LPL) activity and a notable decrease in protein expression of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) were observed, demonstrated that the anti-lipidemic properties of EVP probably via regulation of hepatic LPL and HMGR ( Grifola frondosa polysaccharides (GFP) were proven to be capable of decreasing the levels of fasting blood glucose (FBG), oral glucose tolerance (OGT), TC, TG, and LDL-C in serum, and reducing the hepatic levels of TC, TG, and free fatty acids through inhibiting the expressions of SREBP-1c, ACC, Cd36, and HMGCR, and promoting the expressions of Acox1, Ldlr, CYP7A1, and BSEP in gene levels in high fat diet (HFD) and STZ-induced diabetic mice ( Dictyophora indusiate crude polysaccharides displayed hypolipidemic actions, including a decrease in fat accumulation and serum TG and free fatty acid levels by inhibiting the expressions of lipogenic genes, such as PPAR-, C/EBP, SREBP-1c, acetyl-CoA carboxylase-1 (ACC-1), and FAS ( Sarcodon aspratus could improve lipid metabolism in HFD-induced obese mice by regulating lipogenesis meditators (ACC-1 and PGC-1) ( Numerous animal and human clinical trial studies have demonstrated that dietary polysaccharides, such as plant polysaccharides, mushroom polysaccharides, and alga polysaccharides, have potential anti-hyperlipidemic effects ( G

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