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With consistent healthy habits and proper nutrition, improvements in antioxidant status may occur gradually over several weeks to months

doi: 10.1016/j.redox.2021.102225 78 RiffelmacherTClarkeARichterFCStranksAPandeySDanielliSet al

Important clinical considerations include: The metabolic changes generally track with body weight

The PIONEER trial protocols were approved by institutional review boards or independent ethics committees at the participating trial sites, and the studies were conducted in accordance with ICH Good Clinical Practice guidelines and the Declaration of Helsinki

The chocolate taste is sweet without being cloying, but benefits from mixing with milk instead of the suggested water