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(This can be compared to taking vitamins, where a person takes less but more often)

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Phase 4: adaptation and stabilization (weeks 28 and beyond) The decline in heart rate effects after week 24 reflects genuine physiological adaptation

The critical implication of these findings is that OA should be reconceptualized, in a significant subset of patients, as a systemic metabolic disorder rather than a purely localized joint disease

Gut microbes influence the availability and metabolism of neurotransmitter precursors, including tryptophan (a serotonin precursor) and tyrosine (a dopamine precursor), involved in mood regulation, cognition, and stress resilience

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