Confirming the findings from previous trials, the tirzepatide weight-lowering efficacy was still impressive yet blunted in patients with T2D, as shown in the SURMOUNT 2 trial
Appetite starts shifting gently
The thirst usually shows up within the first few weeks of treatment or after a dose increase, and for most users it settles down within 2 to 4 weeks on a stable dose
Alternate the injection site between the stomach, thigh, and upper arm with each injection
However, a randomized controlled trial that compared once-a-week 2.4 mg of semaglutide to placebo in type 2 diabetes patients found that 67.5% of participants had an HbA1c lower than 48 mmol/mol (6.5%) at the end of 68 weeks
Other potential issues include macula oedema, retinal haemorrhaging due to the worsening of DR, and neovascular (wet) age-related macular degeneration (nAMD), which was reported by JAMA as having a 2-fold higher risk of development due to prolonged of GLP-1 therapy