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Core Therapeutic Value: GLP-1RAs and GLP-1/GIP dual receptor agonists represent fundamental breakthroughs in the treatment of T2DM and obesity

58 Phase 2a trial of GSBR-1290 (120mg) in 40 healthy obese volunteers over 8 weeks demonstrated a significant reduction in BW (120 mg: -4.74%

Ahrn B, Masmiquel L, Kumar H, et al

Its a balanced option that can help you feel energized, even if youre eating less overall

It is better absorbed and retained by most tissues

Although GLP-1 increased cytokine production in resting iNKT cells, both GLP-1 and liraglutide inhibited cytokine secretion following treatment with phorbol myristate acetate/ionomycin, or in iNKT cells activated by co-culture with glycolipid-treated CD1d-transfected C1R cells, actions blocked by the GLP-1R antagonist exendin (939)