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For the loop mutant A42C, biotin modification at this position distorted the adjacent strand E, which in turn allosterically impacts the conformation of the critical catalytic residue Glu77 (Fig

Regulation of metallothionein gene expression by oxidative stress and metal ions

Doctors are urged to closely monitor patients for depression, suicidal thoughts, and unusual behavior changes

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These pleiotropic benefits may be particularly valuable for patients with obesity, metabolic syndrome, or type 2 diabetes who have residual cardiovascular risk despite adequate statin therapy

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