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PMCID: PMC4570055.

The global antioxidant capacity of the epithelial lining fluid, despite an increase in single antioxidant compounds, seems unable to fully counterbalance the increased oxidative burden (108)

Dietary deficiency of riboflavin can decrease the production of NAD and NADP, thereby promoting niacin deficiency

BENEFITS: SKIN GLOW | OXIDATIVE-STRESS REDUCTION | BRIGHTENING | SPOT LIGHTENING & REDUCTION

Chemical and Environmental Sensitivities: By supplying the liver with the necessary substrate for Phase 2 GST conjugation, glutathione enhances the body's ability to detoxify environmental pollutants, heavy metals, and metabolic byproducts that trigger sensitivity flares

The enzyme-catalyzed reverse reaction between GSSG or GSSR and reduced roGFP2 releases roGFP2(SSG) which can instantaneously react via a nonenzymatic shortcut yielding GSH and roGFP2(S 2 ) (Fig