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For instance, theyre generally contraindicated for those with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

In the survodutide arm (a GLP-1 and glucagon receptor dual agonist), liver mass dropped 55% while muscle loss in the casted leg was comparable across semaglutide, survodutide, and pair-fed controls

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The plaintiffs argue that despite the inclusion of warnings on the drug labels, the companies downplayed the severity of gastrointestinal issues