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Direct comparisons of tirzepatide 5, 10 and 15 mg versus semaglutide 1 mg on the refined population of SURPASS2 were also included

reports grants from Amgen, AstraZeneca, Boehringer Ingelheim, FAES, Janssen, Eli Lilly & Company, MSD, Novo Nordisk, Pfizer, Sanofi, Shire and UCB

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Weight loss plateaus are a normal part of the process reflecting metabolic adaptation, not medication failure

Trajectories of BMI change over 12 months Regarding trajectories of percentage BMI change over 12 months, higher semaglutide dose (1.7 mg vs 0.5 or 1.0 mg) and female sex were associated with greater percentage BMI reductions, whereas type 2 diabetes was associated with a lower percentage BMI reduction ( Figure 4 )

For example, the weekly injections Wegovy and Mounjaro, which are brand names for semaglutide and tirzepatide, respectively