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To address its intratumoral delivery limitations, they constructed nanomedicines (SHK@HA-MPDA) by loading shikonin onto mesoporous polydopamine nanoparticles, followed by surface modification with tumor-targeting hyaluronic acid [111]

Genetic removal of basal nitric oxide enhances contractile activity in isolated murine collecting lymphatic vessels

It plays a central role in cellular metabolism, DNA repair, and overall cellular resiliency. As a key regulator of energy production and cellular maintenance, NAD+ enables cells to efficiently convert nutrients into energy and respond to physiological stressfunctions that are fundamental to healthy aging

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