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Cuadrado and colleagues first showed that GSK-3 inhibits NRF2 activity, but the identification of sites in NRF2 that are phosphorylated by GSK-3 was achieved several years later using two-dimensional electrophoresis and mass spectrometry: GSK-3 phosphorylates a group of Ser residues at the level of DSGIS motif in the Neh6 domain of NRF2, and this event represents the signal for the recognition by the adapter protein -TrCP, that targets NRF2 for ubiquitination and proteasomal degradation in a KEAP1-independent manner [150, 151]

Sargent Retired Chair and CEO, Staples, Inc

M.et al (2022a)

It is, however, a foundational strategy that makes any weight management approach, whether pharmaceutical, peptide-based, or lifestyle-only, more effective

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Free radicals (otherwise known as reactive oxygen species) are the bad guys - they destroy your DNA, mitochondria and cells