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Patients can often maintain their weight loss with a lower dose after initial success, which can help balance effectiveness with tolerability. According to Lilly, both trials met their primary and all key secondary endpoints

EC 50 = half-maximal effective concentration

As a result, it remains difficult to distinguish whether these effects represent direct modification of aging biology or improvements in underlying metabolic dysfunction

Associations were estimated using proportional reporting ratio

Mortality is lowest at BMI 22.525 and each 5 kg/m 2 increase in BMI is associated with a 30% higher all-cause mortality as well as 40% higher vascular mortality [8]

The efficacy data: 1