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Animal studies show that DPP-4 inhibition does not improve glucose homeostasis in mice with genetic deletion of GLP-1 and GIP receptors, highlighting the critical role of GLP-1 in the mechanism of action of DPP-4 inhibitors (46)

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HFD feeding induced intestinal inflammation in OLETF rats, however, the role of endotoxemia as a driver of this inflammatory response was questioned as, although systemic LPS levels were increased, systemic cytokine levels remained unchanged (158)