So far, it is hypothesized that (1) on-line benefits to stimulation might be the result of directly modulating Purkinje neuron activity, whereas off-line benefits may be the result from long-lasting changes to the activity of Golgi cells [267, 268], and (2) severe cerebellar atrophy with a major loss of neurons above a threshold is unlikely to respond well to non-invasive stimulation
For repletion of a confirmed deficiency, I use higher doses, typically 1000 to 2000 mcg per day
If someone is following a primarily vegan diet, they may not be getting enough B12 and might not be getting enough dairy. Calcium pills also tend to be really big and tedious, Cording says
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Consider trying high-dose oral B12 when absorption is intact and reassess periodically with your clinician