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In laboratory models, DSIP is associated with modulation of the hypothalamicpituitaryadrenal axis and broader neurochemical signaling processes that govern circadian rhythm, hormonal release, and cellular stress adaptation
Across each phase, patients may face different barriers, from uncertainty about starting therapy to treatment complexity, declining motivation, side effects, or loss of support over time
Because correlation is not causation
Greenberg Z, Gavish H, Muhlrad A, Chorev M, Shteyer A, Attar-Namdar M, et al
However, real-world data shows conflicting persistence trends, with one study revealing that 63% of patients persist for at least one year, while another shows that one-third of people stopped taking their GLP-1 in the first month, and less than half stayed on for more than 12 weeks
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