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Risk of Bias assessment of the included articles was conducted using the Risk of Bias version 2 (RoB2) tool ( Statistical analyses We performed all meta-analyses using RevMan (version 5.4, Cochrane Collaboration)

From a clinical perspective, the right time for reflux repair in patients with medication-induced or medication-worsened reflux is when conservative measures, such as drug therapy and lifestyle changes, fail to provide clear and significant symptom relief

Side effects may be more likely during dose changes or when interacting medicines are added or stopped

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Serotonin regulates a broad range of cognitive functions and behaviors, she said