soul trial oral semaglutide cardiovascular outcomes results 2024 2025 nejm (NEJM 2025): led to a 14% ↓ in major CV events vs placebo in T2DM with ASCVD or CKD — no ↑ in serious AEs. #Semaglutide #CardioDiabetes #updatesinmedicine soul trial oral semaglutide cardiovascular
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