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As a triple receptor agonist targeting GLP-1, GIP, and glucagon pathways simultaneously, retatrutide represents one of the most advanced incretinomimetic compounds under investigation for metabolic and obesity research

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The GIP-induced peripheral promotion of positive energy balance is likely to be far less effective than the GLP- 1/GIP dual agonist's direct action on the central nervous system, which results in satiety and weight loss

In the brain, GHS-R1a is also expressed in areas outside the hypothalamus, such as in the hippocampus, SN, VTA, cortex and amygdala (Guan et al., 1997

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