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The median BMIs in the weight-loss cohort were 35.3 kg/m 2 during year 1 and 30.4 kg/m 2 during year 4, respectively, which represented a median weight loss of 13%

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Introduction The diabetes epidemic poses a significant economic and health burden for society and patients, with its prevalence increasing globally ( Methods The protocol of this study was prospectively registered with PROSPERO (International Prospective Register of Systematic Reviews