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HOXA2 overexpression attenuated renal ER stress and oxidative stress in UUO mice Studies have shown that chronic ER stress promotes a secondary increase in reactive oxygen species (ROS) production, leading to cell death 44

Dysbiosisimbalances in the gut microbiomecan alter immune development and regulation, promoting inflammatory states that facilitate autoimmune activation

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[3] Gene expression

1 Introduction Methionine is one of the essential AA for humans and animals (Franois, 2023) and holds a distinctive position in driving various metabolic pathways