10.1016/j.cortex.2015.08.022 Keywords VX Drug Class: Chemical Warfare Agent classified as a Nerve Agent Mechanism of Action & Effects: Routes of exposure: VX can be absorbed through the eyes or the skin of the victim As little as one drop of VX on the skin can be fatal (as compared to 1 to 10 mls of sarin or soman) The LD50 for humans is estimated to be ~10 mg Notes: Amber (honey brown) colored, tasteless & odorless, oily liquid with low volatility unless temperatures are high The V of VX signifies it very long persistence compared to sarin and soman VX decomposes at a rate of ~ 5% a month at 71 C VX-inhibited cholinesterase can be reactivated by 2-PAM for as long as 48 hours (Sidell & Groff : The reactivatibility of cholinesterase inhibited by VX and sarin in man
whereas others report outcomes as total GSH (e.g., [12, 19, 24, 26,27,28,29,30])
It helps: to boost the Immune system reduce inflammation in detoxification resulting in the protection of organs and tissues and slows aging helps with protein synthesis and a natural building block of structural proteins in connective tissues and in nails and hair enhances the function of citrulline as part of the nitric oxide cycle which improves blood circulation leading to improved semen viscosity, volume and mobility
Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine
This mechanism establishes OLA as a promising anti-fibrotic therapeutic candidate ( Mitochondria-targeted antioxidants or CYP2E1 inhibition prevents this toxicity, highlighting CcO dysfunction as a key pathological mechanism ( Daphnia magna through its reactive metabolite NAPQI
[1] [13] Sites of the pentose phosphate pathway In animal cells and bacteria , the hexose monophosphate shunt, like glycolysis, fatty acid synthesis, and most reactions of gluconeogenesis, occurs in the cytosol