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BA synthesis is regulated through two primary pathways: the FXR/SHP pathway and the FXR/FGF19/FGFR4 pathway

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In a recent study, Liskiewicz and colleagues discovered that long-acting GIP receptor agonists activate GABAergic neurons that express the GIP receptor in the area postrema, and that GIP receptor signaling in GABAergic neurons is necessary for the effects of GIP to lower body weight [151]

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Avoid overeating, skipping protein, and ignoring hydration