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Note: MDPI stays neutral with regard to jurisdictional claims in published Chunarkar-Patil P et al (2024) Anticancer drug discovery based on natural products: from computational approaches to clinical studies

Early studies of oral contraceptives (birth control pills) containing high doses of estrogen indicated adverse effects on folate status

This localized depletion is strongly correlated with increased ventricular lactate, pointing to severe neuroinflammation, an overwhelmed central nervous system antioxidant network, and a direct physiological explanation for the profound cognitive dysfunction and "brain fog" experienced by patients

2016;11:e0149802