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PubMed , World Journal of Gastroenterology , vol

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The synergistic effect of aromatic residues, arginine and negatively charged histidine can enhance the stability of enzyme binding, and the regulation of hydrophobic N-terminal residues on aging-related enzyme activities reveals a new optimization direction

Because retatrutide lowers blood glucose through multiple hormonal pathways, combining it with insulin or sulfonylureas (such as gliclazide or glibenclamide) may substantially increase the risk of hypoglycaemia

Busnelli A, Paffoni A, Fedele L, Somigliana E

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