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Tissue Inhibitor of Metalloproteinase (TIMP) Interactions The balance between MMPs and their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs), determines net proteolytic activity in tissues

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Findings: Preclinical data showed increased collagen-related gene expression and improved tissue remodeling processes

This effect is consistent with what has been observed with other GLP-1 based compounds and is thought to reflect a combination of weight-mediated reduction in vascular resistance and direct vascular effects of GLP-1 receptor activation

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