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The choice of combination therapy should be individualized based on patient-specific factors, including baseline glycemic control, hypoglycemia history, renal function, and cardiovascular risk profile

Patients with DPN frequently experience symmetric sensory disturbances, typically presenting as pain, tingling, and prickling sensations and negative symptoms such as numbness [77]

Patients with prediabetes, type 2 diabetes, or genetic predispositions to obesity often benefit from longer-term treatment because their metabolic dysfunction persists even after initial weight loss

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