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Other contributing factors include: Small intestinal bacterial overgrowth (SIBO) Gastrointestinal infections or parasites Certain medicines that slow digestion (e.g., opioids, anticholinergics, tricyclic antidepressants, GLP-1 receptor agonists) Food intolerances or malabsorption disorders Swallowing excess air (aerophagia) Consumption of carbonated beverages Understanding the underlying cause is essential for effective management

Cultured human keratinocytes have been suggested as good models to predict dermal irritancy of substances in human subjects 31

2019;179:1129-1143.e23

An intermediate goal has been to develop vaccines against a subset of these viruses, referred to as broadly protective coronavirus vaccines rather than pan- or universal vaccines

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Nutr Cancer 2011;63(5):663672