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Neural Regen Res

Comorbidities: Type 2 diabetes: Both are FDA-approved for diabetes (tirzepatide as Mounjaro, semaglutide as Ozempic) Cardiovascular disease: Semaglutide has the cardiovascular outcomes data Sleep apnea: Tirzepatide has shown benefits Injection frequency: Both are once-weekly

Exenatide, a synthetic variant of exendin-4, incorporates strategic modifications that substitute asparagine (Asn) at the C-terminal with aspartic acid (Asp) and swap alanine (Ala) at the 8 th position with glycine (Gly)

GLP-1R is expressed in the AP and nucleus of the solitary tract (NTS) located in the hindbrain, and c-Fos expression after GLP-1RA injection was apparent in hindbrain GLP-1R cells, with further studies demonstrating these cells role in mediating GLP-1RA actions [59,96,102,103]

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Research shows that 10% weight loss can reduce urinary incontinence symptoms by up to 47%