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In the beagle dog model induced by the combination of alloxan and STZ, the levels of BNIP3, NIX, and FUNDC1 were significantly upregulated, indicating that DKD can induce non-ubiquitin-dependent mitophagy, and N-acetyl-L-cysteine (NAC) treatment reduced the levels of BNIP3, NIX, and FUNDC1, suggesting that NAC can alleviate mitophagy and reduce kidney damage in DKD [154]

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Severe depression or suicidal thoughts mood shifts have been noted in post-marketing reports

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