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This approach is particularly valuable in long-term protocols exceeding 8-12 weeks where continuous single-compound administration might produce diminishing returns through tolerance development

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Video: Retatrutide Phase 3 Results in Context Before enrolling, it helps to understand what the program has shown so far

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The least-squares mean percentage change in body weight at 24 weeks in the retatrutide groups was -7.2% in the 1-mg group, -12.9% in the combined 4-mg group, -17.3% in the combined 8-mg group, and -17.5% in the 12-mg group, as compared with -1.6% in the placebo group