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Researchers commonly utilise MT-2 in broader in-vitro studies involving receptor-related signalling models and peptide stability investigations

Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

Along with dedicated methods for analysis of biomarkers of exposure to distinct mycotoxins, multi-mycotoxin methods are increasingly applied for the simultaneous determination of multiple analytes as described in the previous chapter

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